1. Kuipers R.S., Luxwolda M.F., Dijck-Brouwer D.J., Eaton S.B., Crawford M.A., Cordain L., Muskiet F.A. Estimated macronutrient and fatty acid intakes from an East African Paleolithic diet. Br. J. Nutr. 2010;104:1666–1687. doi: 10.1017/S0007114510002679. [PubMed] [CrossRef] [Google Scholar] Show 2. Eaton S.B., Eaton S.B., 3rd, Sinclair A.J., Cordain L., Mann N.J. Dietary intake of long-chain polyunsaturated fatty acids during the paleolithic. World Rev. Nutr. Diet. 1998;83:12–23. [PubMed] [Google Scholar] 3. Singh R.B., Demeester F., Wilczynska A. The tsim tsoum approaches for prevention of cardiovascular disease. Cardiol. Res. Pract. 2010;2010:824938. doi: 10.4061/2010/824938. [PMC free article] [PubMed] [CrossRef] [Google Scholar] 4. Rodriguez-Leyva D., Dupasquier C.M., McCullough R., Pierce G.N. The cardiovascular effects of flaxseed and its omega-3 fatty acid, alpha-linolenic acid. Can. J. Cardiol. 2010;26:489–496. doi: 10.1016/S0828-282X(10)70455-4. [PMC free article] [PubMed] [CrossRef] [Google Scholar] 5. Simopoulos A.P., DiNicolantonio J.J. The importance of a balanced omega-6 to omega-3 ratio in the prevention and management of obesity. Open Heart. 2016;3:e000385. doi: 10.1136/openhrt-2015-000385. [PMC free article] [PubMed] [CrossRef] [Google Scholar] 6. Blasbalg T.L., Hibbeln J.R., Ramsden C.E., Majchrzak S.F., Rawlings R.R. Changes in consumption of omega-3 and omega-6 fatty acids in the United States during the 20th century. Am. J. Clin. Nutr. 2011;93:950–962. doi: 10.3945/ajcn.110.006643. [PMC free article] [PubMed] [CrossRef] [Google Scholar] 7. Simopoulos A.P., Leaf A., Salem N., Jr. Workshop on the Essentiality of and Recommended Dietary Intakes for Omega-6 and Omega-3 Fatty Acids. J. Am. Coll. Nutr. 1999;18:487–489. doi: 10.1080/07315724.1999.10718888. [PubMed] [CrossRef] [Google Scholar] 8. Guyenet S.J., Carlson S.E. Increase in adipose tissue linoleic acid of US adults in the last half century. Adv. Nutr. 2015;6:660–664. doi: 10.3945/an.115.009944. [PMC free article] [PubMed] [CrossRef] [Google Scholar] 9. Klerman G.L., Weissman M.M. Increasing rates of depression. JAMA. 1989;261:2229–2235. doi: 10.1001/jama.1989.03420150079041. [PubMed] [CrossRef] [Google Scholar] 10. Jadoon A., Chiu C.C., McDermott L., Cunningham P., Frangou S., Chang C.J., Sun I.W., Liu S.I., Lu M.L., Su K.P., et al. Associations of polyunsaturated fatty acids with residual depression or anxiety in older people with major depression. J. Affect. Disord. 2012;136:918–925. doi: 10.1016/j.jad.2011.09.007. [PubMed] [CrossRef] [Google Scholar] 11. Wolfe A.R., Ogbonna E.M., Lim S., Li Y., Zhang J. Dietary linoleic and oleic fatty acids in relation to severe depressed mood: 10 years follow-up of a national cohort. Prog. Neuropsychopharmacol Biol. Psychiatry. 2009;33:972–977. doi: 10.1016/j.pnpbp.2009.05.002. [PubMed] [CrossRef] [Google Scholar] 12. da Rocha C.M., Kac G. High dietary ratio of omega-6 to omega-3 polyunsaturated acids during pregnancy and prevalence of post-partum depression. Matern. Child Nutr. 2012;8:36–48. doi: 10.1111/j.1740-8709.2010.00256.x. [PMC free article] [PubMed] [CrossRef] [Google Scholar] 13. Lucas M., Mirzaei F., O’Reilly E.J., Pan A., Willett W.C., Kawachi I., Koenen K., Ascherio A. Dietary intake of n-3 and n-6 fatty acids and the risk of clinical depression in women: A 10-y prospective follow-up study. Am. J. Clin. Nutr. 2011;93:1337–1343. doi: 10.3945/ajcn.111.011817. [PMC free article] [PubMed] [CrossRef] [Google Scholar] 14. Barcelo-Coblijn G., Murphy E.J. Alpha-linolenic acid and its conversion to longer chain n-3 fatty acids: Benefits for human health and a role in maintaining tissue n-3 fatty acid levels. Prog. Lipid Res. 2009;48:355–374. doi: 10.1016/j.plipres.2009.07.002. [PubMed] [CrossRef] [Google Scholar] 15. Burdge G.C., Wootton S.A. Conversion of alpha-linolenic acid to eicosapentaenoic, docosapentaenoic and docosahexaenoic acids in young women. Br. J. Nutr. 2002;88:411–420. doi: 10.1079/BJN2002689. [PubMed] [CrossRef] [Google Scholar] 16. Docosahexaenoic acid (DHA). Monograph. Altern. Med. Rev. 2009;14:391–399. [PubMed] [Google Scholar] 17. Jump D.B. The biochemistry of n-3 polyunsaturated fatty acids. J. Biol. Chem. 2002;277:8755–8758. doi: 10.1074/jbc.R100062200. [PubMed] [CrossRef] [Google Scholar] 18. Gibson R.A., Neumann M.A., Makrides M. Effect of increasing breast milk docosahexaenoic acid on plasma and erythrocyte phospholipid fatty acids and neural indices of exclusively breast fed infants. Eur. J. Clin. Nutr. 1997;51:578–584. doi: 10.1038/sj.ejcn.1600446. [PubMed] [CrossRef] [Google Scholar] 19. Anderson G.J., Neuringer M., Lin D.S., Connor W.E. Can prenatal N-3 fatty acid deficiency be completely reversed after birth? Effects on retinal and brain biochemistry and visual function in rhesus monkeys. Pediatr. Res. 2005;58:865–872. doi: 10.1203/01.pdr.0000182188.31596.5a. [PubMed] [CrossRef] [Google Scholar] 20. Youdim K.A., Martin A., Joseph J.A. Essential fatty acids and the brain: Possible health implications. Int. J. Dev. Neurosci. 2000;18:383–399. doi: 10.1016/S0736-5748(00)00013-7. [PubMed] [CrossRef] [Google Scholar] 22. Bowen R.A., Clandinin M.T. Maternal dietary 22: 6n-3 is more effective than 18: 3n-3 in increasing the 22: 6n-3 content in phospholipids of glial cells from neonatal rat brain. Br. J. Nutr. 2005;93:601–611. doi: 10.1079/BJN20041390. [PubMed] [CrossRef] [Google Scholar] 23. Blank C., Neumann M.A., Makrides M., Gibson R.A. Optimizing DHA levels in piglets by lowering the linoleic acid to alpha-linolenic acid ratio. J. Lipid Res. 2002;43:1537–1543. doi: 10.1194/jlr.M200152-JLR200. [PubMed] [CrossRef] [Google Scholar] 24. Menkes J.H. Early feeding history of children with learning disorders. Dev. Med. Child Neurol. 1977;19:169–171. doi: 10.1111/j.1469-8749.1977.tb07966.x. [PubMed] [CrossRef] [Google Scholar] 25. Rodgers B. Feeding in infancy and later ability and attainment: A longitudinal study. Dev. Med. Child Neurol. 1978;20:421–426. doi: 10.1111/j.1469-8749.1978.tb15242.x. [PubMed] [CrossRef] [Google Scholar] 26. Taylor B., Wadsworth J. Breast feeding and child development at five years. Dev. Med. Child Neurol. 1984;26:73–80. doi: 10.1111/j.1469-8749.1984.tb04409.x. [PubMed] [CrossRef] [Google Scholar] 27. Al M.D., Badart-Smook A., von Houwelingen A.C., Hasaart T.H., Hornstra G. Fat intake of women during normal pregnancy: Relationship with maternal and neonatal essential fatty acid status. J. Am. Coll. Nutr. 1996;15:49–55. doi: 10.1080/07315724.1996.10718564. [PubMed] [CrossRef] [Google Scholar] 28. Hornstra G. Essential fatty acids in mothers and their neonates. Am. J. Clin. Nutr. 2000;71:1262s–1269s. doi: 10.1093/ajcn/71.5.1262s. [PubMed] [CrossRef] [Google Scholar] 29. Foreman-van Drongelen M.M., Zeijdner E.E., van Houwelingen A.C., van Houwelingen A.C., Kester A.D., Al M.D., Hasaart T.H., Hornstra G. Essential fatty acid status measured in umbilical vessel walls of infants born after a multiple pregnancy. Early Hum. Dev. 1996;46:205–215. doi: 10.1016/0378-3782(96)01745-8. [PubMed] [CrossRef] [Google Scholar] 30. Zeijdner E.E., van Houwelingen A.C., Kester A.D., Hornstra G. Essential fatty acid status in plasma phospholipids of mother and neonate after multiple pregnancy. Prostaglandins Leukot. Essent. Fatty Acids. 1997;56:395–401. doi: 10.1016/S0952-3278(97)90590-1. [PubMed] [CrossRef] [Google Scholar] 31. Sugano M., Ikeda I. Metabolic interactions between essential and trans-fatty acids. Curr. Opin. Lipidol. 1996;7:38–42. doi: 10.1097/00041433-199602000-00009. [PubMed] [CrossRef] [Google Scholar] 32. Carlson S.E., Werkman S.H., Peeples J.M., Wilson W.M. Long-chain fatty acids and early visual and cognitive development of preterm infants. Eur. J. Clin. Nutr. 1994;48(Suppl. 2):S27–S30. [PubMed] [Google Scholar] 33. Carlson S.E., Werkman S.H. A randomized trial of visual attention of preterm infants fed docosahexaenoic acid until two months. Lipids. 1996;31:85–90. doi: 10.1007/BF02522416. [PubMed] [CrossRef] [Google Scholar] 34. Werkman S.H., Carlson S.E. A randomized trial of visual attention of preterm infants fed docosahexaenoic acid until nine months. Lipids. 1996;31:91–97. doi: 10.1007/BF02522417. [PubMed] [CrossRef] [Google Scholar] 35. Willatts P., Forsyth J.S., DiModugno M.K., Varma S., Colvin M. Effect of long-chain polyunsaturated fatty acids in infant formula on problem solving at 10 months of age. Lancet. 1998;352:688–691. doi: 10.1016/S0140-6736(97)11374-5. [PubMed] [CrossRef] [Google Scholar] 36. Lucas A., Morley R., Cole T.J., Lister G., Leeson-Payne C. Breast milk and subsequent intelligence quotient in children born preterm. Lancet. 1992;339:261–264. doi: 10.1016/0140-6736(92)91329-7. [PubMed] [CrossRef] [Google Scholar] 37. Rogan W.J., Gladen B.C. Breast-feeding and cognitive development. Early Hum. Dev. 1993;31:181–193. doi: 10.1016/0378-3782(93)90194-Y. [PubMed] [CrossRef] [Google Scholar] 38. Horwood L.J., Fergusson D.M. Breastfeeding and later cognitive and academic outcomes. Pediatrics. 1998;101:E9. doi: 10.1542/peds.101.1.e9. [PubMed] [CrossRef] [Google Scholar] 39. Lanting C.I., Fidler V., Huisman M., Touwen B.C., Boersma E.R. Neurological differences between 9-year-old children fed breast-milk or formula-milk as babies. Lancet. 1994;344:1319–1322. doi: 10.1016/S0140-6736(94)90692-0. [PubMed] [CrossRef] [Google Scholar] 40. Agostoni C., Trojan S., Bellu R., Riva E., Giovannini M. Neurodevelopmental quotient of healthy term infants at 4 months and feeding practice: The role of long-chain polyunsaturated fatty acids. Pediatr. Res. 1995;38:262–266. doi: 10.1203/00006450-199508000-00021. [PubMed] [CrossRef] [Google Scholar] 41. Agostoni C., Riva E., Trojan S., Bellu R., Giovannini M. Docosahexaenoic acid status and developmental quotient of healthy term infants. Lancet. 1995;346:638. doi: 10.1016/S0140-6736(95)91469-2. [PubMed] [CrossRef] [Google Scholar] 42. Agostoni C., Trojan S., Bellu R., Riva E., Bruzzese M.G., Giovannini M. Developmental quotient at 24 months and fatty acid composition of diet in early infancy: A follow up study. Arch. Dis. Child. 1997;76:421–424. doi: 10.1136/adc.76.5.421. [PMC free article] [PubMed] [CrossRef] [Google Scholar] 43. Birch E.E., Birch D.G., Hoffman D.R., Uauy R. Dietary essential fatty acid supply and visual acuity development. Invest. Ophthalmol. Vis. Sci. 1992;33:3242–3253. [PubMed] [Google Scholar] 44. Carlson S.E., Werkman S.H., Tolley E.A. Effect of long-chain n-3 fatty acid supplementation on visual acuity and growth of preterm infants with and without bronchopulmonary dysplasia. Am. J. Clin. Nutr. 1996;63:687–697. doi: 10.1093/ajcn/63.5.687. [PubMed] [CrossRef] [Google Scholar] 45. Carlson S.E., Werkman S.H., Rhodes P.G., Tolley E.A. Visual-acuity development in healthy preterm infants:Effect of marine-oil supplementation. Am. J. Clin. Nutr. 1993;58:35–42. doi: 10.1093/ajcn/58.1.35. [PubMed] [CrossRef] [Google Scholar] 46. Makrides M., Neumann M., Simmer K., Pater J., Gibson R. Are long-chain polyunsaturated fatty acids essential nutrients in infancy? Lancet. 1995;345:1463–1468. doi: 10.1016/S0140-6736(95)91035-2. [PubMed] [CrossRef] [Google Scholar] 47. Birch E.E., Hoffman D.R., Uauy R., Birch D.G., Prestidge C. Visual acuity and the essentiality of docosahexaenoic acid and arachidonic acid in the diet of term infants. Pediatr. Res. 1998;44:201–209. doi: 10.1203/00006450-199808000-00011. [PubMed] [CrossRef] [Google Scholar] 48. Carlson S.E., Ford A.J., Werkman S.H., Peeples J.M., Koo W.W. Visual acuity and fatty acid status of term infants fed human milk and formulas with and without docosahexaenoate and arachidonate from egg yolk lecithin. Pediatr. Res. 1996;39:882–888. doi: 10.1203/00006450-199605000-00024. [PubMed] [CrossRef] [Google Scholar] 49. Auestad N., Montalto M.B., Hall R.T., Fitzgerald K.M., Wheeler R.E., Connor W.E., Neuringer M., Connor S.L., Taylor J.A., Hartmann E.E. Visual acuity, erythrocyte fatty acid composition, and growth in term infants fed formulas with long chain polyunsaturated fatty acids for one year. Ross Pediatric Lipid Study. Pediatr. Res. 1997;41:1–10. doi: 10.1203/00006450-199701000-00001. [PubMed] [CrossRef] [Google Scholar] 50. Innis S.M., Nelson C.M., Rioux M.F., King D.J. Development of visual acuity in relation to plasma and erythrocyte omega-6 and omega-3 fatty acids in healthy term gestation infants. Am. J. Clin. Nutr. 1994;60:347–352. doi: 10.1093/ajcn/60.3.347. [PubMed] [CrossRef] [Google Scholar] 51. Innis S.M., Nelson C.M., Lwanga D., Rioux F.M., Waslen P. Feeding formula without arachidonic acid and docosahexaenoic acid has no effect on preferential looking acuity or recognition memory in healthy full-term infants at 9 mo of age. Am. J. Clin. Nutr. 1996;64:40–46. doi: 10.1093/ajcn/64.1.40. [PubMed] [CrossRef] [Google Scholar] 52. Innis S.M., Akrabawi S.S., Diersen-Schade D.A., Dobson M.V., Guy D.G. Visual acuity and blood lipids in term infants fed human milk or formulae. Lipids. 1997;32:63–72. doi: 10.1007/s11745-997-0010-7. [PubMed] [CrossRef] [Google Scholar] 53. Kidd P.M. Omega-3 DHA and EPA for cognition, behavior, and mood: Clinical findings and structural-functional synergies with cell membrane phospholipids. Altern. Med. Rev. 2007;12:207–227. [PubMed] [Google Scholar] 54. Hirayama S., Hamazaki T., Terasawa K. Effect of docosahexaenoic acid-containing food administration on symptoms of attention-deficit/hyperactivity disorder—A placebo-controlled double-blind study. Eur. J. Clin. Nutr. 2004;58:467–473. doi: 10.1038/sj.ejcn.1601830. [PubMed] [CrossRef] [Google Scholar] 55. Stevens L., Zhang W., Peck L., Kuczek T., Grevstad N., Mahon A., Zentall S.S., Arnold L.E., Burgess J.R. EFA supplementation in children with inattention, hyperactivity, and other disruptive behaviors. Lipids. 2003;38:1007–1021. doi: 10.1007/s11745-006-1155-0. [PubMed] [CrossRef] [Google Scholar] 56. Johnson M., Ostlund S., Fransson G., Kadesjo B., Gillberg C. Omega-3/omega-6 fatty acids for attention deficit hyperactivity disorder: A randomized placebo-controlled trial in children and adolescents. J. Atten. Disord. 2009;12:394–401. doi: 10.1177/1087054708316261. [PubMed] [CrossRef] [Google Scholar] 57. Richardson A.J., Burton J.R., Sewell R.P., Spreckelsen T.F., Montgomery P. Docosahexaenoic acid for reading, cognition and behavior in children aged 7–9 years: A randomized, controlled trial (the DOLAB Study) PLoS ONE. 2012;7:e43909. doi: 10.1371/journal.pone.0043909. [PMC free article] [PubMed] [CrossRef] [Google Scholar] 58. Vaisman N., Kaysar N., Zaruk-Adasha Y., Pelled D., Brichon G., Zwingelstein G., Bodennec J. Correlation between changes in blood fatty acid composition and visual sustained attention performance in children with inattention: Effect of dietary n-3 fatty acids containing phospholipids. Am. J. Clin. Nutr. 2008;87:1170–1180. doi: 10.1093/ajcn/87.5.1170. [PubMed] [CrossRef] [Google Scholar] 59. Manor I., Magen A., Keidar D., Rosen S., Tasker H., Cohen T., Richter Y., Zaaroor-Regev D., Manor Y., Weizman A. The effect of phosphatidylserine containing Omega3 fatty-acids on attention-deficit hyperactivity disorder symptoms in children: A double-blind placebo-controlled trial, followed by an open-label extension. Eur. Psychiatry. 2012;27:335–342. doi: 10.1016/j.eurpsy.2011.05.004. [PubMed] [CrossRef] [Google Scholar] 60. Richardson A.J., Montgomery P. The Oxford-Durham study: A randomized, controlled trial of dietary supplementation with fatty acids in children with developmental coordination disorder. Pediatrics. 2005;115:1360–1366. doi: 10.1542/peds.2004-2164. [PubMed] [CrossRef] [Google Scholar] 61. Vancassel S., Durand G., Barthelemy C., Lejeune B., Martineau J., Guilloteau D., Andres C., Chalon S. Plasma fatty acid levels in autistic children. Prostaglandins Leukot. Essent. Fatty Acids. 2001;65:1–7. doi: 10.1054/plef.2001.0281. [PubMed] [CrossRef] [Google Scholar] 62. Amminger G.P., Berger G.E., Schafer M.R., Klier C., Friedrich M.H., Feucht M. Omega-3 fatty acids supplementation in children with autism: A double-blind randomized, placebo-controlled pilot study. Biol. Psychiatry. 2007;61:551–553. doi: 10.1016/j.biopsych.2006.05.007. [PubMed] [CrossRef] [Google Scholar] 63. Logan A.C. Neurobehavioral aspects of omega-3 fatty acids: Possible mechanisms and therapeutic value in major depression. Altern. Med. Rev. 2003;8:410–425. [PubMed] [Google Scholar] 64. Kornstein S.G., Schneider R.K. Clinical features of treatment-resistant depression. J. Clin. Psychiatry. 2001;62(Suppl. 16):18–25. [PubMed] [Google Scholar] 65. Lin P.Y., Huang S.Y., Su K.P. A meta-analytic review of polyunsaturated fatty acid compositions in patients with depression. Biol. Psychiatry. 2010;68:140–147. doi: 10.1016/j.biopsych.2010.03.018. [PubMed] [CrossRef] [Google Scholar] 66. Tanskanen A., Hibbeln J.R., Tuomilehto J., Uutela A., Haukkala A., Viinamaki H., Lehtonen J., Vartiainen E. Fish consumption and depressive symptoms in the general population in Finland. Psychiatr. Serv. 2001;52:529–531. doi: 10.1176/appi.ps.52.4.529. [PubMed] [CrossRef] [Google Scholar] 67. Fontani G., Corradeschi F., Felici A., Alfatti F., Migliorini S., Lodi L. Cognitive and physiological effects of Omega-3 polyunsaturated fatty acid supplementation in healthy subjects. Eur. J. Clin. Investig. 2005;35:691–699. doi: 10.1111/j.1365-2362.2005.01570.x. [PubMed] [CrossRef] [Google Scholar] 68. Maes M., Smith R.S. Fatty acids, cytokines, and major depression. Biol. Psychiatry. 1998;43:313–314. [PubMed] [Google Scholar] 69. Suarez E.C., Krishnan R.R., Lewis J.G. The relation of severity of depressive symptoms to monocyte-associated proinflammatory cytokines and chemokines in apparently healthy men. Psychosom. Med. 2003;65:362–368. doi: 10.1097/01.PSY.0000035719.79068.2B. [PubMed] [CrossRef] [Google Scholar] 70. Xia Z., DePierre J.W., Nassberger L. Tricyclic antidepressants inhibit IL-6, IL-1 beta and TNF-alpha release in human blood monocytes and IL-2 and interferon-gamma in T cells. Immunopharmacology. 1996;34:27–37. doi: 10.1016/0162-3109(96)00111-7. [PubMed] [CrossRef] [Google Scholar] 71. Hibbeln J.R. Fish consumption and major depression. Lancet. 1998;351:1213. doi: 10.1016/S0140-6736(05)79168-6. [PubMed] [CrossRef] [Google Scholar] 72. Hibbeln J.R., Gow R.V. The potential for military diets to reduce depression, suicide, and impulsive aggression: A review of current evidence for omega-3 and omega-6 fatty acids. Mil. Med. 2014;179:117–128. doi: 10.7205/MILMED-D-14-00153. [PubMed] [CrossRef] [Google Scholar] 73. Silvers K.M., Scott K.M. Fish consumption and self-reported physical and mental health status. Public Health Nutr. 2002;5:427–431. doi: 10.1079/PHN2001308. [PubMed] [CrossRef] [Google Scholar] 74. Hibbeln J.R. Seafood consumption, the DHA content of mothers’ milk and prevalence rates of postpartum depression: A cross-national, ecological analysis. J. Affect. Disord. 2002;69:15–29. doi: 10.1016/S0165-0327(01)00374-3. [PubMed] [CrossRef] [Google Scholar] 75. Adams P.B., Lawson S., Sanigorski A., Sinclair A.J. Arachidonic acid to eicosapentaenoic acid ratio in blood correlates positively with clinical symptoms of depression. Lipids. 1996;31:S157–S161. doi: 10.1007/BF02637069. [PubMed] [CrossRef] [Google Scholar] 76. Tiemeier H., van Tuijl H.R., Hofman A., Kiliaan A.J., Breteler M.M. Plasma fatty acid composition and depression are associated in the elderly: The Rotterdam Study. Am. J. Clin. Nutr. 2003;78:40–46. doi: 10.1093/ajcn/78.1.40. [PubMed] [CrossRef] [Google Scholar] 77. Mamalakis G., Tornaritis M., Kafatos A. Depression and adipose essential polyunsaturated fatty acids. Prostaglandins Leukot. Essent. Fatty Acids. 2002;67:311–318. doi: 10.1054/plef.2002.0435. [PubMed] [CrossRef] [Google Scholar] 78. Frasure-Smith N., Lesperance F., Julien P. Major depression is associated with lower omega-3 fatty acid levels in patients with recent acute coronary syndromes. Biol. Psychiatry. 2004;55:891–896. doi: 10.1016/j.biopsych.2004.01.021. [PubMed] [CrossRef] [Google Scholar] 79. De Vriese S.R., Christophe A.B., Maes M. Lowered serum n-3 polyunsaturated fatty acid (PUFA) levels predict the occurrence of postpartum depression: Further evidence that lowered n-PUFAs are related to major depression. Life Sci. 2003;73:3181–3187. doi: 10.1016/j.lfs.2003.02.001. [PubMed] [CrossRef] [Google Scholar] 80. Green P., Hermesh H., Monselise A., Marom S., Presburger G., Weizman A. Red cell membrane omega-3 fatty acids are decreased in nondepressed patients with social anxiety disorder. Eur. Neuropsychopharmac. 2006;16:107–113. doi: 10.1016/j.euroneuro.2005.07.005. [PubMed] [CrossRef] [Google Scholar] 81. Chiu C.C., Huang S.Y., Su K.P., Lu M.L., Huang M.C., Chen C.C., Shen W.W. Polyunsaturated fatty acid deficit in patients with bipolar mania. Eur. Neuropsychopharmac. 2003;13:99–103. doi: 10.1016/S0924-977X(02)00130-X. [PubMed] [CrossRef] [Google Scholar] 82. McNamara R.K., Hahn C.G., Jandacek R., Rider T., Tso P., Stanford K.E., Richtand N.M. Selective deficits in the omega-3 fatty acid docosahexaenoic acid in the postmortem orbitofrontal cortex of patients with major depressive disorder. Biol. Psychiatry. 2007;62:17–24. doi: 10.1016/j.biopsych.2006.08.026. [PubMed] [CrossRef] [Google Scholar] 83. Nemets B., Stahl Z., Belmaker R.H. Addition of omega-3 fatty acid to maintenance medication treatment for recurrent unipolar depressive disorder. Am. J. Psychiatry. 2002;159:477–479. doi: 10.1176/appi.ajp.159.3.477. [PubMed] [CrossRef] [Google Scholar] 84. Zanarini M.C., Frankenburg F.R. omega-3 Fatty acid treatment of women with borderline personality disorder: A double-blind, placebo-controlled pilot study. Am. J. Psychiatry. 2003;160:167–169. doi: 10.1176/appi.ajp.160.1.167. [PubMed] [CrossRef] [Google Scholar] 85. Su K.P., Huang S.Y., Chiu C.C., Shen W.W. Omega-3 fatty acids in major depressive disorder. A preliminary double-blind, placebo-controlled trial. Eur. Neuropsychopharmac. 2003;13:267–271. doi: 10.1016/S0924-977X(03)00032-4. [PubMed] [CrossRef] [Google Scholar] 86. Peet M., Horrobin D.F. A dose-ranging study of the effects of ethyl-eicosapentaenoate in patients with ongoing depression despite apparently adequate treatment with standard drugs. Arch. Gen. Psychiatry. 2002;59:913–919. doi: 10.1001/archpsyc.59.10.913. [PubMed] [CrossRef] [Google Scholar] 87. Grosso G., Pajak A., Marventano S., Castellano S., Galvano F., Bucolo C., Drago F., Caraci F. Role of omega-3 fatty acids in the treatment of depressive disorders: A comprehensive meta-analysis of randomized clinical trials. PLoS ONE. 2014;9:e96905. doi: 10.1371/journal.pone.0096905. [PMC free article] [PubMed] [CrossRef] [Google Scholar] 88. Jazayeri S., Tehrani-Doost M., Keshavarz S.A., Hosseini M., Djazayery A., Amini H., Jalali M., Peet M. Comparison of therapeutic effects of omega-3 fatty acid eicosapentaenoic acid and fluoxetine, separately and in combination, in major depressive disorder. Aust. N. Z. J. Psychiatry. 2008;42:192–198. doi: 10.1080/00048670701827275. [PubMed] [CrossRef] [Google Scholar] 89. Frangou S., Lewis M., McCrone P. Efficacy of ethyl-eicosapentaenoic acid in bipolar depression: Randomised double-blind placebo-controlled study. Br. J. Psychiatry. 2006;188:46–50. doi: 10.1192/bjp.188.1.46. [PubMed] [CrossRef] [Google Scholar] 90. Nemets H., Nemets B., Apter A., Bracha Z., Belmaker R.H. Omega-3 treatment of childhood depression: A controlled, double-blind pilot study. Am. J. Psychiatry. 2006;163:1098–1100. doi: 10.1176/ajp.2006.163.6.1098. [PubMed] [CrossRef] [Google Scholar] 91. Su K.P., Huang S.Y., Chiu T.H., Huang K.C., Huang C.L., Chang H.C., Pariante C.M. Omega-3 fatty acids for major depressive disorder during pregnancy: Results from a randomized, double-blind, placebo-controlled trial. J. Clin. Psychiatry. 2008;69:644–651. doi: 10.4088/JCP.v69n0418. [PubMed] [CrossRef] [Google Scholar] 92. Da Silva T.M., Munhoz R.P., Alvarez C., Naliwaiko K., Kiss A., Andreatini R., Ferraz A.C. Depression in Parkinson’s disease: A double-blind, randomized, placebo-controlled pilot study of omega-3 fatty-acid supplementation. J. Affect. Disord. 2008;111:351–359. doi: 10.1016/j.jad.2008.03.008. [PubMed] [CrossRef] [Google Scholar] 93. De Vriese S.R., Christophe A.B., Maes M. In humans, the seasonal variation in poly-unsaturated fatty acids is related to the seasonal variation in violent suicide and serotonergic markers of violent suicide. Prostaglandins Leukot. Essent. Fatty Acids. 2004;71:13–18. doi: 10.1016/j.plefa.2003.12.002. [PubMed] [CrossRef] [Google Scholar] 94. Lewis M.D., Hibbeln J.R., Johnson J.E., Lin Y.H., Hyun D.Y., Loewke J.D. Suicide deaths of active-duty US military and omega-3 fatty-acid status: A case-control comparison. J. Clin. Psychiatry. 2011;72:1585–1590. doi: 10.4088/JCP.11m06879. [PMC free article] [PubMed] [CrossRef] [Google Scholar] 95. Huan M., Hamazaki K., Sun Y., Itomura M., Liu H., Kang W., Watanabe S., Terasawa K., Hamazaki T. Suicide attempt and n-3 fatty acid levels in red blood cells: A case control study in China. Biol. Psychiatry. 2004;56:490–496. doi: 10.1016/j.biopsych.2004.06.028. [PubMed] [CrossRef] [Google Scholar] 96. Hallahan B., Hibbeln J.R., Davis J.M., Garland M.R. Omega-3 fatty acid supplementation in patients with recurrent self-harm. Single-centre double-blind randomised controlled trial. Br. J. Psychiatry. 2007;190:118–122. doi: 10.1192/bjp.bp.106.022707. [PubMed] [CrossRef] [Google Scholar] 97. Lucas M., Asselin G., Merette C., Poulin M.J., Dodin S. Ethyl-eicosapentaenoic acid for the treatment of psychological distress and depressive symptoms in middle-aged women: A double-blind, placebo-controlled, randomized clinical trial. Am. J. Clin. Nutr. 2009;89:641–651. doi: 10.3945/ajcn.2008.26749. [PubMed] [CrossRef] [Google Scholar] 98. Rondanelli M., Giacosa A., Opizzi A., Pelucchi C., La Vecchia C., Montorfano G., Negroni M., Berra B., Politi P., Rizzo A.M. Effect of omega-3 fatty acids supplementation on depressive symptoms and on health-related quality of life in the treatment of elderly women with depression: A double-blind, placebo-controlled, randomized clinical trial. J. Am. Coll. Nutr. 2010;29:55–64. doi: 10.1080/07315724.2010.10719817. [PubMed] [CrossRef] [Google Scholar] 99. Sinn N., Milte C.M., Street S.J., Buckley J.D., Coates A.M., Petkov J., Howe P.R. Effects of n-3 fatty acids, EPA v. DHA, on depressive symptoms, quality of life, memory and executive function in older adults with mild cognitive impairment: A 6-month randomised controlled trial. Br. J. Nutr. 2012;107:1682–1693. doi: 10.1017/S0007114511004788. [PubMed] [CrossRef] [Google Scholar] 100. Clayton E.H., Hanstock T.L., Hirneth S.J., Kable C.J., Garg M.L., Hazell P.L. Reduced mania and depression in juvenile bipolar disorder associated with long-chain omega-3 polyunsaturated fatty acid supplementation. Eur. J. Clin. Nutr. 2009;63:1037–1040. doi: 10.1038/ejcn.2008.81. [PubMed] [CrossRef] [Google Scholar] 101. Richardson A.J., Puri B.K. A randomized double-blind, placebo-controlled study of the effects of supplementation with highly unsaturated fatty acids on ADHD-related symptoms in children with specific learning difficulties. Prog. Neuropsychopharmac. Biol. Psychiatry. 2002;26:233–239. doi: 10.1016/S0278-5846(01)00254-8. [PubMed] [CrossRef] [Google Scholar] 102. Mamalakis G., Kalogeropoulos N., Andrikopoulos N., Hatzis C., Kromhout D., Moschandreas J., Kafatos A. Depression and long chain n-3 fatty acids in adipose tissue in adults from Crete. Eur. J. Clin. Nutr. 2006;60:882–888. doi: 10.1038/sj.ejcn.1602394. [PubMed] [CrossRef] [Google Scholar] 103. Assies J., Lieverse R., Vreken P., Wanders R.J., Dingemans P.M., Linszen D.H. Significantly reduced docosahexaenoic and docosapentaenoic acid concentrations in erythrocyte membranes from schizophrenic patients compared with a carefully matched control group. Biol. Psychiatry. 2001;49:510–522. doi: 10.1016/S0006-3223(00)00986-0. [PubMed] [CrossRef] [Google Scholar] 104. Hamazaki T., Sawazaki S., Itomura M., Nagao Y., Thienprasert A., Nagasawa T., Watanabe S. Effect of docosahexaenoic acid on hostility. World Rev. Nutr. Diet. 2001;88:47–52. [PubMed] [Google Scholar] 105. Mamalakis G., Kafatos A., Tornaritis M., Alevizos B. Anxiety and adipose essential fatty acid precursors for prostaglandin E1 and E2. J. Am. Coll. Nutr. 1998;17:239–243. doi: 10.1080/07315724.1998.10718753. [PubMed] [CrossRef] [Google Scholar] 106. Shakeri J., Khanegi M., Golshani S., Farnia V., Tatari F., Alikhani M., Nooripour R., Ghezelbash M.S. Effects of Omega-3 Supplement in the Treatment of Patients with Bipolar I Disorder. Int. J. Prev. Med. 2016;7:77. [PMC free article] [PubMed] [Google Scholar] 107. Vesco A.T., Lehmann J., Gracious B.L., Arnold L.E., Young A.S., Fristad M.A. Omega-3 Supplementation for Psychotic Mania and Comorbid Anxiety in Children. J. Child Adolesc. Psychopharmacol. 2015;25:526–534. doi: 10.1089/cap.2013.0141. [PMC free article] [PubMed] [CrossRef] [Google Scholar] 108. Cott J., Hibbeln J.R. Lack of seasonal mood change in Icelanders. Am. J. Psychiatry. 2001;158:328. doi: 10.1176/appi.ajp.158.2.328. [PubMed] [CrossRef] [Google Scholar] What are 2 key nutrients for brain health?If you'd like to stay sharper, faster and more focused, these five nutrients for the brain can help.. Lutein. This plant pigment is found in every part of the brain, and it aids in learning and memory. ... . DHA Omega-3. Did you know that fat makes up nearly 60% of your brain? ... . B Vitamins. ... . Vitamin D. ... . Protein.. What is the best vitamin for brain and eyes?Your brain and cognitive health are essential for skills like hand-eye coordination, depth perception, and eye teaming. On top of this, they can also improve your memory and reduce the risk of Alzheimer's disease. Look for foods and supplements rich in vitamin K, lutein, omega-3 fatty acids, folate, and beta carotene. What are the key nutrients that support the brain and eyes?Three nutrients are especially important to support the developing brain and eyes: Lutein, Vitamin E, and DHA. "These key nutrients work together to support brain and eye health," explains Abbott registered dietitian and pediatric nutrition scientist, Beth Reverri, PhD, RD. What is the best nutrient for your eyes?Researchers have linked eye-friendly nutrients, such as lutein and zeaxanthin, vitamin C, vitamin E and zinc, to reducing the risk of certain serious eye diseases like age-related macular degeneration and cataracts. You can find these antioxidants in green leafy vegetables, fruits, nuts and a lot of other foods. |
